Drug interactions
Carbachol + Ipratropium-salbutamol
Severity: Moderate
Carbachol and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbachol is a cholinergic agonist and ipratropium is a muscarinic antagonist, so they pharmacologically oppose each other. Ipratropium may reduce the effect of carbachol, for example miosis or bladder stimulation, though with inhaled use systemic exposure is low.
What this interaction means in plain words
Carbachol and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbachol belongs to Miscellaneous; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for reduced carbachol effect, and increase the carbachol dose or choose an alternative if its effect is lost. Avoid nebulizer mist reaching the eyes when carbachol is used ophthalmically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Carbachol
- Atropine + Carbachol Moderate
- Bethanechol + Carbachol Moderate
- Carbachol + Darifenacin Moderate
- Carbachol + Dicyclomine Moderate
- Carbachol + Donepezil Moderate
- Carbachol + Flavoxate Moderate
Frequently asked questions
Can I take Carbachol with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Carbachol and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbachol is a cholinergic agonist and ipratropium is a muscarinic antagonist, so they pharmacologically oppose each other. Ipratropium may reduce the effect of carbachol, for example miosis or bladder stimulation, though with inhaled use systemic exposure is low.
How serious is the interaction between Carbachol and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced carbachol effect, and increase the carbachol dose or choose an alternative if its effect is lost. Avoid nebulizer mist reaching the eyes when carbachol is used ophthalmically.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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