Drug interactions
Carbachol + Maprotiline
Severity: Minor
Carbachol and Maprotiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbachol is a cholinergic agonist, and maprotiline has antimuscarinic activity that may oppose its effects. Clinical significance is uncertain, especially because carbachol is mostly used topically in the eye.
What this interaction means in plain words
Carbachol and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbachol belongs to Miscellaneous; Maprotiline belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between a cholinergic agonist and an antimuscarinic antidepressant.
What to do
No specific action beyond awareness; monitor for reduced miotic effect if carbachol is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Carbachol
- Atropine + Carbachol Moderate
- Bethanechol + Carbachol Moderate
- Carbachol + Darifenacin Moderate
- Carbachol + Dicyclomine Moderate
- Carbachol + Donepezil Moderate
- Carbachol + Flavoxate Moderate
Frequently asked questions
Can I take Carbachol with Maprotiline?
MediHelp rates the interaction as minor. Carbachol and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbachol is a cholinergic agonist, and maprotiline has antimuscarinic activity that may oppose its effects. Clinical significance is uncertain, especially because carbachol is mostly used topically in the eye.
How serious is the interaction between Carbachol and Maprotiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action beyond awareness; monitor for reduced miotic effect if carbachol is used.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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