Drug interactions
Carbamazepine + Clonazepam
Severity: Moderate
Carbamazepine and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces CYP3A4 and can lower clonazepam concentrations, with possible loss of seizure control. Clonazepam may in turn have a small effect on carbamazepine levels, and both cause sedation.
What this interaction means in plain words
Carbamazepine and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Clonazepam belongs to Central Nervous System.
Why it happens
Carbamazepine induces CYP3A4, increasing clonazepam clearance.
What to do
Monitor seizure control and sedation, and adjust the clonazepam dose as needed. Consider measuring carbamazepine levels if toxicity or loss of control is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Clonazepam?
MediHelp rates the interaction as moderate. Carbamazepine and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces CYP3A4 and can lower clonazepam concentrations, with possible loss of seizure control. Clonazepam may in turn have a small effect on carbamazepine levels, and both cause sedation.
How serious is the interaction between Carbamazepine and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and sedation, and adjust the clonazepam dose as needed. Consider measuring carbamazepine levels if toxicity or loss of control is suspected.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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