Drug interactions
Carbamazepine + Cyclophosphamide
Severity: Moderate
Carbamazepine and Cyclophosphamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces hepatic enzymes including CYP2B6 and CYP3A4, increasing conversion of cyclophosphamide to its active and toxic metabolites. This may alter efficacy and raise the risk of metabolite-related toxicity.
What this interaction means in plain words
Carbamazepine and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Cyclophosphamide belongs to Oncology.
Why it happens
Induction of CYP2B6 and CYP3A4 accelerates cyclophosphamide bioactivation.
What to do
Monitor for increased toxicity such as myelosuppression and hemorrhagic cystitis, or consider a non-inducing antiepileptic such as levetiracetam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Cyclophosphamide?
MediHelp rates the interaction as moderate. Carbamazepine and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces hepatic enzymes including CYP2B6 and CYP3A4, increasing conversion of cyclophosphamide to its active and toxic metabolites. This may alter efficacy and raise the risk of metabolite-related toxicity.
How serious is the interaction between Carbamazepine and Cyclophosphamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased toxicity such as myelosuppression and hemorrhagic cystitis, or consider a non-inducing antiepileptic such as levetiracetam.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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