Drug interactions
Carbamazepine + Docetaxel
Severity: Moderate
Carbamazepine and Docetaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine, a strong CYP3A4 inducer, can lower docetaxel exposure and may reduce its antitumor effect.
What this interaction means in plain words
Carbamazepine and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Docetaxel belongs to Oncology.
Why it happens
Carbamazepine induces CYP3A4, increasing docetaxel clearance.
What to do
Prefer a non-enzyme-inducing antiseizure drug. If unavoidable, monitor clinical response to docetaxel.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Docetaxel
Frequently asked questions
Can I take Carbamazepine with Docetaxel?
MediHelp rates the interaction as moderate. Carbamazepine and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine, a strong CYP3A4 inducer, can lower docetaxel exposure and may reduce its antitumor effect.
How serious is the interaction between Carbamazepine and Docetaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-enzyme-inducing antiseizure drug. If unavoidable, monitor clinical response to docetaxel.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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