Drug interactions
Carbamazepine + Dosulepin
Severity: Moderate
Carbamazepine and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can lower dosulepin exposure, which may reduce antidepressant effect. Carbamazepine also has structural and pharmacodynamic overlap with tricyclics, adding to anticholinergic and cardiac conduction effects.
What this interaction means in plain words
Carbamazepine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Dosulepin belongs to Central Nervous System.
Why it happens
Carbamazepine induces hepatic CYP enzymes (including CYP3A4, CYP1A2 and CYP2C19) that metabolize tricyclic antidepressants.
What to do
Monitor depressive symptoms and consider raising the dosulepin dose guided by clinical response. Review the dose when carbamazepine is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carbamazepine and Dosulepin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Carbamazepine with Dosulepin?
MediHelp rates the interaction as moderate. Carbamazepine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine can lower dosulepin exposure, which may reduce antidepressant effect. Carbamazepine also has structural and pharmacodynamic overlap with tricyclics, adding to anticholinergic and cardiac conduction effects.
How serious is the interaction between Carbamazepine and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor depressive symptoms and consider raising the dosulepin dose guided by clinical response. Review the dose when carbamazepine is started or stopped.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
