Drug interactions
Carbamazepine + Eprosartan-hydrochlorothiazide
Severity: Moderate
Carbamazepine and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can cause hyponatremia through SIADH-like effects, and thiazide diuretics also waste sodium. Combined use increases the chance of clinically significant hyponatremia, with confusion, headache, falls or seizures.
What this interaction means in plain words
Carbamazepine and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive sodium-lowering effects: carbamazepine enhances renal water retention while hydrochlorothiazide increases renal sodium loss.
What to do
Check serum sodium at baseline and periodically, especially in the first weeks and in older patients. Switch the diuretic or reassess therapy if sodium falls or symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Carbamazepine and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine can cause hyponatremia through SIADH-like effects, and thiazide diuretics also waste sodium. Combined use increases the chance of clinically significant hyponatremia, with confusion, headache, falls or seizures.
How serious is the interaction between Carbamazepine and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and periodically, especially in the first weeks and in older patients. Switch the diuretic or reassess therapy if sodium falls or symptoms appear.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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