Drug interactions
Carbamazepine + Fesoterodine
Severity: Moderate
Carbamazepine and Fesoterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces CYP3A4 and can lower exposure to the active metabolite of fesoterodine, 5-hydroxymethyl tolterodine. This may reduce effectiveness for overactive bladder.
What this interaction means in plain words
Carbamazepine and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Fesoterodine belongs to Genitourinary.
Why it happens
CYP3A4 induction increases clearance of the active metabolite of fesoterodine.
What to do
Monitor for reduced symptom control and consider titrating fesoterodine to 8 mg daily as labeled, or switch agents if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Fesoterodine?
MediHelp rates the interaction as moderate. Carbamazepine and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces CYP3A4 and can lower exposure to the active metabolite of fesoterodine, 5-hydroxymethyl tolterodine. This may reduce effectiveness for overactive bladder.
How serious is the interaction between Carbamazepine and Fesoterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced symptom control and consider titrating fesoterodine to 8 mg daily as labeled, or switch agents if the response is inadequate.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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