Drug interactions
Carbamazepine + Fludrocortisone
Severity: Moderate
Carbamazepine and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may lower fludrocortisone exposure and reduce its mineralocorticoid effect. This could lead to inadequate control in adrenal insufficiency, with hypotension or hyponatremia.
What this interaction means in plain words
Carbamazepine and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Fludrocortisone belongs to Endocrine.
Why it happens
Carbamazepine induces CYP3A4 and speeds corticosteroid metabolism.
What to do
Monitor blood pressure, serum sodium and potassium, and increase the fludrocortisone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Carbamazepine with Fludrocortisone?
MediHelp rates the interaction as moderate. Carbamazepine and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may lower fludrocortisone exposure and reduce its mineralocorticoid effect. This could lead to inadequate control in adrenal insufficiency, with hypotension or hyponatremia.
How serious is the interaction between Carbamazepine and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum sodium and potassium, and increase the fludrocortisone dose if needed.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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