Drug interactions
Carbamazepine + Flurbiprofen
Severity: Minor
Carbamazepine and Flurbiprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces hepatic enzymes and may lower flurbiprofen exposure, possibly reducing therapeutic effect. The clinical significance is likely limited.
What this interaction means in plain words
Carbamazepine and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Carbamazepine induction of CYP2C9 increases flurbiprofen metabolism.
What to do
Monitor for reduced analgesic effect and adjust flurbiprofen dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Flurbiprofen?
MediHelp rates the interaction as minor. Carbamazepine and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbamazepine induces hepatic enzymes and may lower flurbiprofen exposure, possibly reducing therapeutic effect. The clinical significance is likely limited.
How serious is the interaction between Carbamazepine and Flurbiprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced analgesic effect and adjust flurbiprofen dose if needed.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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