Drug interactions
Carbamazepine + Fluvastatin
Severity: Minor
Carbamazepine and Fluvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces enzymes and may lower fluvastatin levels, which could reduce its effect. Fluvastatin is cleared mainly by CYP2C9, with a smaller contribution from CYP3A4, so the induction effect is likely modest.
What this interaction means in plain words
Carbamazepine and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Fluvastatin belongs to Cardiovascular.
Why it happens
Carbamazepine induces CYP enzymes, modestly increasing fluvastatin metabolism.
What to do
Monitor the lipid response and adjust the fluvastatin dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Fluvastatin?
MediHelp rates the interaction as minor. Carbamazepine and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbamazepine induces enzymes and may lower fluvastatin levels, which could reduce its effect. Fluvastatin is cleared mainly by CYP2C9, with a smaller contribution from CYP3A4, so the induction effect is likely modest.
How serious is the interaction between Carbamazepine and Fluvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the lipid response and adjust the fluvastatin dose if needed.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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