Drug interactions
Carbamazepine + Frovatriptan
Severity: Minor
Carbamazepine and Frovatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may modestly reduce frovatriptan exposure. Clinical consequences are probably limited, as frovatriptan has multiple clearance pathways and a wide therapeutic margin.
What this interaction means in plain words
Carbamazepine and Frovatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Frovatriptan belongs to Central Nervous System.
Why it happens
Carbamazepine induces CYP1A2, which contributes to frovatriptan metabolism.
What to do
No routine adjustment is needed. If migraine response is inadequate, consider another triptan or a repeat dose per labeling.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Carbamazepine with Frovatriptan?
MediHelp rates the interaction as minor. Carbamazepine and Frovatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbamazepine may modestly reduce frovatriptan exposure. Clinical consequences are probably limited, as frovatriptan has multiple clearance pathways and a wide therapeutic margin.
How serious is the interaction between Carbamazepine and Frovatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. If migraine response is inadequate, consider another triptan or a repeat dose per labeling.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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