Drug interactions
Carbamazepine + Givinostat
Severity: Moderate
Carbamazepine and Givinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat is a weak CYP3A4 inhibitor and may modestly raise carbamazepine levels. Carbamazepine, a strong inducer, may also lower givinostat exposure.
What this interaction means in plain words
Carbamazepine and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Givinostat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 inhibition by givinostat, and induction of givinostat metabolism by carbamazepine.
What to do
Monitor carbamazepine concentrations and toxicity, and monitor givinostat efficacy and tolerability. Adjust doses according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Carbamazepine with Givinostat?
MediHelp rates the interaction as moderate. Carbamazepine and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat is a weak CYP3A4 inhibitor and may modestly raise carbamazepine levels. Carbamazepine, a strong inducer, may also lower givinostat exposure.
How serious is the interaction between Carbamazepine and Givinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor carbamazepine concentrations and toxicity, and monitor givinostat efficacy and tolerability. Adjust doses according to response.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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