Drug interactions
Carbamazepine + Glyburide-metformin
Severity: Moderate
Carbamazepine and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces hepatic enzymes, including CYP2C9 and CYP3A4, and can lower glyburide concentrations. This may lead to loss of glycemic control.
What this interaction means in plain words
Carbamazepine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Glyburide-metformin belongs to Endocrine.
Why it happens
Induction of CYP2C9 and CYP3A4 increases glyburide metabolism.
What to do
Monitor blood glucose after starting or stopping carbamazepine and adjust the glyburide dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Glyburide-metformin?
MediHelp rates the interaction as moderate. Carbamazepine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces hepatic enzymes, including CYP2C9 and CYP3A4, and can lower glyburide concentrations. This may lead to loss of glycemic control.
How serious is the interaction between Carbamazepine and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping carbamazepine and adjust the glyburide dose accordingly.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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