Drug interactions
Carbamazepine + Hydrochlorothiazide-telmisartan
Severity: Moderate
Carbamazepine and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazide diuretics and carbamazepine can lower serum sodium. Used together they may cause clinically significant hyponatremia, with symptoms ranging from confusion to seizures.
What this interaction means in plain words
Carbamazepine and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Additive effects on sodium handling: thiazide-induced renal sodium loss plus carbamazepine-related antidiuretic effect.
What to do
Check serum sodium at baseline and periodically, especially after starting or changing doses and in older patients. Consider an alternative antihypertensive if sodium falls significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Carbamazepine and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazide diuretics and carbamazepine can lower serum sodium. Used together they may cause clinically significant hyponatremia, with symptoms ranging from confusion to seizures.
How serious is the interaction between Carbamazepine and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and periodically, especially after starting or changing doses and in older patients. Consider an alternative antihypertensive if sodium falls significantly.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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