Drug interactions
Carbamazepine + Hydrochlorothiazide-valsartan
Severity: Moderate
Carbamazepine and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both carbamazepine and thiazide diuretics can cause hyponatremia, and together the risk of clinically significant low sodium rises. Symptoms include confusion, headache, nausea and seizures. Older patients are at particular risk.
What this interaction means in plain words
Carbamazepine and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive effects on sodium handling: carbamazepine enhances antidiuretic hormone effect while thiazides increase renal sodium loss.
What to do
Check serum sodium at baseline and periodically, particularly after starting or adjusting either drug. Switch the diuretic or reduce doses if sodium falls significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Carbamazepine and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both carbamazepine and thiazide diuretics can cause hyponatremia, and together the risk of clinically significant low sodium rises. Symptoms include confusion, headache, nausea and seizures. Older patients are at particular risk.
How serious is the interaction between Carbamazepine and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and periodically, particularly after starting or adjusting either drug. Switch the diuretic or reduce doses if sodium falls significantly.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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