Drug interactions
Carbamazepine + Ifosfamide
Severity: Moderate
Carbamazepine and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may increase the bioactivation of ifosfamide to its alkylating metabolites. This may increase myelosuppression, neurotoxicity and nephrotoxicity, although it may also change the formation of the toxic chloroacetaldehyde metabolite.
What this interaction means in plain words
Carbamazepine and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Ifosfamide belongs to Oncology.
Why it happens
Carbamazepine induces CYP3A4 and CYP2B6, which increases ifosfamide activation and formation of toxic metabolites.
What to do
Monitor for neurotoxicity, renal function and blood counts during ifosfamide treatment. Consider a non-inducing antiepileptic if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Carbamazepine with Ifosfamide?
MediHelp rates the interaction as moderate. Carbamazepine and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may increase the bioactivation of ifosfamide to its alkylating metabolites. This may increase myelosuppression, neurotoxicity and nephrotoxicity, although it may also change the formation of the toxic chloroacetaldehyde metabolite.
How serious is the interaction between Carbamazepine and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurotoxicity, renal function and blood counts during ifosfamide treatment. Consider a non-inducing antiepileptic if toxicity appears.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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