Drug interactions
Carbamazepine + Metformin-pioglitazone
Severity: Moderate
Carbamazepine and Metformin-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can lower pioglitazone concentrations and may reduce glucose-lowering efficacy.
What this interaction means in plain words
Carbamazepine and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Carbamazepine induces CYP3A4 and CYP2C8, increasing pioglitazone metabolism.
What to do
Monitor glucose and HbA1c after starting or stopping carbamazepine, and adjust the pioglitazone dose if control changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Metformin-pioglitazone?
MediHelp rates the interaction as moderate. Carbamazepine and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine can lower pioglitazone concentrations and may reduce glucose-lowering efficacy.
How serious is the interaction between Carbamazepine and Metformin-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting or stopping carbamazepine, and adjust the pioglitazone dose if control changes.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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