Drug interactions
Carbamazepine + Nateglinide
Severity: Moderate
Carbamazepine and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may reduce nateglinide concentrations and weaken glycemic control. After carbamazepine is withdrawn, nateglinide exposure may rise and hypoglycemia may occur.
What this interaction means in plain words
Carbamazepine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Nateglinide belongs to Endocrine.
Why it happens
Carbamazepine induces CYP2C9 and CYP3A4, which metabolize nateglinide.
What to do
Monitor blood glucose when carbamazepine is started, adjusted or stopped. Increase the nateglinide dose if control is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Carbamazepine with Nateglinide?
MediHelp rates the interaction as moderate. Carbamazepine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may reduce nateglinide concentrations and weaken glycemic control. After carbamazepine is withdrawn, nateglinide exposure may rise and hypoglycemia may occur.
How serious is the interaction between Carbamazepine and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when carbamazepine is started, adjusted or stopped. Increase the nateglinide dose if control is poor.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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