Drug interactions
Carbamazepine + Pioglitazone
Severity: Moderate
Carbamazepine and Pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may reduce pioglitazone concentrations and weaken glycemic control. The effect is predicted from induction and is not well characterized.
What this interaction means in plain words
Carbamazepine and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Pioglitazone belongs to Endocrine.
Why it happens
Carbamazepine induces CYP3A4 and CYP2C8, increasing pioglitazone metabolism.
What to do
Monitor blood glucose and HbA1c when carbamazepine is started or stopped. Adjust the pioglitazone dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Pioglitazone
Frequently asked questions
Can I take Carbamazepine with Pioglitazone?
MediHelp rates the interaction as moderate. Carbamazepine and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may reduce pioglitazone concentrations and weaken glycemic control. The effect is predicted from induction and is not well characterized.
How serious is the interaction between Carbamazepine and Pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when carbamazepine is started or stopped. Adjust the pioglitazone dose as needed.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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