Drug interactions
Carbamazepine + Repaglinide
Severity: Moderate
Carbamazepine and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can lower repaglinide concentrations and weaken glycemic control. The effect may be lost or reversed when carbamazepine is withdrawn.
What this interaction means in plain words
Carbamazepine and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Repaglinide belongs to Endocrine.
Why it happens
Carbamazepine induces CYP3A4 and CYP2C8, increasing repaglinide metabolism.
What to do
Monitor blood glucose and adjust the repaglinide dose when carbamazepine is started or stopped. Consider an alternative antidiabetic if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Carbamazepine with Repaglinide?
MediHelp rates the interaction as moderate. Carbamazepine and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine can lower repaglinide concentrations and weaken glycemic control. The effect may be lost or reversed when carbamazepine is withdrawn.
How serious is the interaction between Carbamazepine and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and adjust the repaglinide dose when carbamazepine is started or stopped. Consider an alternative antidiabetic if control is inadequate.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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