Drug interactions
Carbamazepine + Ropinirole
Severity: Moderate
Carbamazepine and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces CYP1A2 and may lower ropinirole exposure, which is mainly cleared by CYP1A2. Parkinson or restless legs symptoms could worsen.
What this interaction means in plain words
Carbamazepine and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Ropinirole belongs to Central Nervous System.
Why it happens
Carbamazepine induces CYP1A2, increasing ropinirole metabolism.
What to do
Monitor symptom control and increase ropinirole dose if needed. Reduce the dose again if carbamazepine is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Ropinirole?
MediHelp rates the interaction as moderate. Carbamazepine and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces CYP1A2 and may lower ropinirole exposure, which is mainly cleared by CYP1A2. Parkinson or restless legs symptoms could worsen.
How serious is the interaction between Carbamazepine and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and increase ropinirole dose if needed. Reduce the dose again if carbamazepine is withdrawn.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
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