Drug interactions
Carbamazepine + Suvorexant
Severity: Moderate
Carbamazepine and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine, a CYP3A4 inducer, lowers suvorexant exposure and may reduce its hypnotic effect.
What this interaction means in plain words
Carbamazepine and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases suvorexant clearance.
What to do
Monitor efficacy and raise suvorexant dose only if needed within labeled maximum, or choose another hypnotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Carbamazepine with Suvorexant?
MediHelp rates the interaction as moderate. Carbamazepine and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine, a CYP3A4 inducer, lowers suvorexant exposure and may reduce its hypnotic effect.
How serious is the interaction between Carbamazepine and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor efficacy and raise suvorexant dose only if needed within labeled maximum, or choose another hypnotic.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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