Drug interactions
Carbamazepine + Valsartan
Severity: Minor
Carbamazepine and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a strong inducer of metabolic enzymes and is not an OATP1B1 inhibitor, so valsartan exposure is more likely to fall than rise. Valsartan is only minimally metabolized, so any effect is probably small.
What this interaction means in plain words
Carbamazepine and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Valsartan belongs to Cardiovascular.
Why it happens
Enzyme and transporter induction by carbamazepine may modestly increase valsartan clearance; the legacy inhibition mechanism is not supported.
What to do
Monitor blood pressure when carbamazepine is started or stopped and adjust valsartan if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Valsartan?
MediHelp rates the interaction as minor. Carbamazepine and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbamazepine is a strong inducer of metabolic enzymes and is not an OATP1B1 inhibitor, so valsartan exposure is more likely to fall than rise. Valsartan is only minimally metabolized, so any effect is probably small.
How serious is the interaction between Carbamazepine and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when carbamazepine is started or stopped and adjust valsartan if needed.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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