Drug interactions
Carbamazepine + Vincristine
Severity: Moderate
Carbamazepine and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzyme-inducing anticonvulsants such as carbamazepine increase vincristine clearance and reduce exposure. This may compromise anti-cancer efficacy.
What this interaction means in plain words
Carbamazepine and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Vincristine belongs to Oncology.
Why it happens
CYP3A4 induction by carbamazepine increases vincristine metabolism.
What to do
Switch to a non-inducing antiseizure drug such as levetiracetam where feasible. Otherwise monitor treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Carbamazepine with Vincristine?
MediHelp rates the interaction as moderate. Carbamazepine and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzyme-inducing anticonvulsants such as carbamazepine increase vincristine clearance and reduce exposure. This may compromise anti-cancer efficacy.
How serious is the interaction between Carbamazepine and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Switch to a non-inducing antiseizure drug such as levetiracetam where feasible. Otherwise monitor treatment response.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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