Drug interactions
Carbamazepine + Vinorelbine
Severity: Moderate
Carbamazepine and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may lower vinorelbine concentrations by inducing CYP3A4, the main enzyme metabolizing it. Reduced exposure may diminish anti-tumor effect.
What this interaction means in plain words
Carbamazepine and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Vinorelbine belongs to Oncology.
Why it happens
CYP3A4 induction by carbamazepine increases vinorelbine clearance.
What to do
Use a non-inducing antiseizure drug if possible. If not, monitor for reduced efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Vinorelbine
Frequently asked questions
Can I take Carbamazepine with Vinorelbine?
MediHelp rates the interaction as moderate. Carbamazepine and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may lower vinorelbine concentrations by inducing CYP3A4, the main enzyme metabolizing it. Reduced exposure may diminish anti-tumor effect.
How serious is the interaction between Carbamazepine and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing antiseizure drug if possible. If not, monitor for reduced efficacy.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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