Drug interactions
Carbenoxolone + Hydrochlorothiazide-irbesartan
Severity: Moderate
Carbenoxolone and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity causing sodium retention and potassium loss, which adds to thiazide-induced hypokalemia and may counteract blood pressure control. Hypokalemia can promote arrhythmias.
What this interaction means in plain words
Carbenoxolone and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of 11-beta-hydroxysteroid dehydrogenase leads to mineralocorticoid excess that adds to thiazide kaliuresis.
What to do
Monitor serum potassium and blood pressure, and replace potassium as needed; consider an alternative to carbenoxolone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Carbenoxolone with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Carbenoxolone and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like activity causing sodium retention and potassium loss, which adds to thiazide-induced hypokalemia and may counteract blood pressure control. Hypokalemia can promote arrhythmias.
How serious is the interaction between Carbenoxolone and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, and replace potassium as needed; consider an alternative to carbenoxolone.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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