Drug interactions
Carbenoxolone + Sotalol
Severity: Major
Carbenoxolone and Sotalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity and can cause sodium retention and hypokalemia. Low potassium raises the risk of QT prolongation and torsade de pointes in patients taking sotalol.
What this interaction means in plain words
Carbenoxolone and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Carbenoxolone-induced hypokalemia adds to the dose-dependent QT-prolonging effect of sotalol.
What to do
Avoid the combination if possible; otherwise monitor serum potassium and magnesium and the QTc interval, and correct deficits promptly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Carbenoxolone with Sotalol?
MediHelp rates the interaction as major. Carbenoxolone and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbenoxolone has mineralocorticoid-like activity and can cause sodium retention and hypokalemia. Low potassium raises the risk of QT prolongation and torsade de pointes in patients taking sotalol.
How serious is the interaction between Carbenoxolone and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor serum potassium and magnesium and the QTc interval, and correct deficits promptly.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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