Drug interactions
Carbidopa + Enalapril-hydrochlorothiazide
Severity: Moderate
Carbidopa and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbidopa, usually given with levodopa, is associated with orthostatic hypotension when combined with antihypertensives. The effect is typically from levodopa, but patients on enalapril and a thiazide may need blood-pressure review.
What this interaction means in plain words
Carbidopa and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa belongs to Central Nervous System; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive hypotension from levodopa-derived dopamine effects alongside ACE inhibition and diuresis.
What to do
Monitor standing and sitting blood pressure when starting carbidopa-levodopa and reduce antihypertensive doses if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Carbidopa
Frequently asked questions
Can I take Carbidopa with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Carbidopa and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa, usually given with levodopa, is associated with orthostatic hypotension when combined with antihypertensives. The effect is typically from levodopa, but patients on enalapril and a thiazide may need blood-pressure review.
How serious is the interaction between Carbidopa and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor standing and sitting blood pressure when starting carbidopa-levodopa and reduce antihypertensive doses if symptomatic.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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