Drug interactions
Carbidopa + Felodipine
Severity: Moderate
Carbidopa and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbidopa is given with levodopa, which can cause orthostatic hypotension, and this adds to felodipine's blood pressure lowering. Carbidopa alone has little hypotensive effect.
What this interaction means in plain words
Carbidopa and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa belongs to Central Nervous System; Felodipine belongs to Cardiovascular.
Why it happens
Additive hypotensive effects of levodopa-related dopaminergic action and vasodilation.
What to do
Monitor orthostatic blood pressure when starting levodopa/carbidopa and reduce the felodipine dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Carbidopa
Frequently asked questions
Can I take Carbidopa with Felodipine?
MediHelp rates the interaction as moderate. Carbidopa and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa is given with levodopa, which can cause orthostatic hypotension, and this adds to felodipine's blood pressure lowering. Carbidopa alone has little hypotensive effect.
How serious is the interaction between Carbidopa and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when starting levodopa/carbidopa and reduce the felodipine dose if hypotension develops.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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