Drug interactions
Carbidopa + Hydrochlorothiazide-losartan
Severity: Moderate
Carbidopa and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbidopa, usually given with levodopa, can add to the blood pressure lowering of antihypertensives and cause orthostatic hypotension. The effect is mainly due to levodopa and is typically manageable.
What this interaction means in plain words
Carbidopa and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa belongs to Central Nervous System; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from dopaminergic therapy and antihypertensive drugs.
What to do
Monitor blood pressure, including orthostatic readings, when starting carbidopa-levodopa and reduce the antihypertensive dose if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Carbidopa
Frequently asked questions
Can I take Carbidopa with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Carbidopa and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa, usually given with levodopa, can add to the blood pressure lowering of antihypertensives and cause orthostatic hypotension. The effect is mainly due to levodopa and is typically manageable.
How serious is the interaction between Carbidopa and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including orthostatic readings, when starting carbidopa-levodopa and reduce the antihypertensive dose if symptomatic.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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