Drug interactions
Carbidopa + Irbesartan
Severity: Moderate
Carbidopa and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbidopa, usually given with levodopa, can contribute to orthostatic hypotension, largely through levodopa. This may add to the blood pressure lowering of irbesartan.
What this interaction means in plain words
Carbidopa and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa belongs to Central Nervous System; Irbesartan belongs to Cardiovascular.
Why it happens
Additive hypotensive effects, mainly from levodopa-derived dopamine given with carbidopa.
What to do
Monitor blood pressure, including standing readings, when starting or adjusting levodopa/carbidopa. Reduce the irbesartan dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Other interactions of Carbidopa
Frequently asked questions
Can I take Carbidopa with Irbesartan?
MediHelp rates the interaction as moderate. Carbidopa and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa, usually given with levodopa, can contribute to orthostatic hypotension, largely through levodopa. This may add to the blood pressure lowering of irbesartan.
How serious is the interaction between Carbidopa and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, when starting or adjusting levodopa/carbidopa. Reduce the irbesartan dose if symptomatic hypotension occurs.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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