Drug interactions
Carbidopa-entacapone-levodopa + Dopamine
Severity: Moderate
Carbidopa-entacapone-levodopa and Dopamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entacapone blocks COMT, which contributes to the breakdown of dopamine. Infused dopamine may have a stronger and longer effect, raising the risk of tachycardia, arrhythmia and blood pressure swings. Levodopa also adds dopaminergic effects.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Dopamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Dopamine belongs to Cardiovascular.
Why it happens
COMT inhibition by entacapone decreases metabolism of exogenous dopamine, with additive dopaminergic activity from levodopa.
What to do
Start dopamine at a low dose and titrate slowly while monitoring ECG and blood pressure. Reduce the dose if arrhythmia or excessive pressor response occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
- Desipramine + Dopamine Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Dopamine?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Dopamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entacapone blocks COMT, which contributes to the breakdown of dopamine. Infused dopamine may have a stronger and longer effect, raising the risk of tachycardia, arrhythmia and blood pressure swings. Levodopa also adds dopaminergic effects.
How serious is the interaction between Carbidopa-entacapone-levodopa and Dopamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start dopamine at a low dose and titrate slowly while monitoring ECG and blood pressure. Reduce the dose if arrhythmia or excessive pressor response occurs.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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