Drug interactions
Dihydroergotamine intranasal + Dopamine
Severity: Contraindicated
Dihydroergotamine intranasal and Dopamine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal dihydroergotamine is systemically absorbed and, together with dopamine, can cause additive vasoconstriction. This may produce severe hypertension and peripheral or cerebral ischemia.
What this interaction means in plain words
Dihydroergotamine intranasal and Dopamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive vasoconstriction from ergot alkaloid activity and dopamine adrenergic effects.
What to do
Avoid concurrent use. Use a different migraine therapy while dopamine is required.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dopamine
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
- Desipramine + Dopamine Major
- Dextroamphetamine + Dopamine Major
Frequently asked questions
Can I take Dihydroergotamine intranasal with Dopamine?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Dopamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Intranasal dihydroergotamine is systemically absorbed and, together with dopamine, can cause additive vasoconstriction. This may produce severe hypertension and peripheral or cerebral ischemia.
How serious is the interaction between Dihydroergotamine intranasal and Dopamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. Use a different migraine therapy while dopamine is required.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine, Selegiline transdermal, Amitriptyline. The full list is on the Dopamine page.
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