Drug interactions
Desipramine + Dopamine
Severity: Major
Desipramine and Dopamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine strongly blocks norepinephrine reuptake and can potentiate pressor and arrhythmic effects of sympathomimetics. Dopamine response may be exaggerated.
What this interaction means in plain words
Desipramine and Dopamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desipramine belongs to Central Nervous System; Dopamine belongs to Cardiovascular.
Why it happens
Blockade of norepinephrine reuptake alters response to dopamine.
What to do
Begin dopamine at a low dose and titrate with continuous blood pressure and ECG monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
- Dextroamphetamine + Dopamine Major
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Dopamine?
MediHelp rates the interaction as major. Desipramine and Dopamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Desipramine strongly blocks norepinephrine reuptake and can potentiate pressor and arrhythmic effects of sympathomimetics. Dopamine response may be exaggerated.
How serious is the interaction between Desipramine and Dopamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin dopamine at a low dose and titrate with continuous blood pressure and ECG monitoring.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Selegiline transdermal. The full list is on the Dopamine page.
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