Drug interactions
Carbidopa-entacapone-levodopa + Gepirone
Severity: Minor
Carbidopa-entacapone-levodopa and Gepirone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is cleared mainly by CYP3A4, and inhibitors raise its exposure, increasing dizziness, sedation and QT prolongation. Entacapone is not an established CYP3A4 inhibitor, so the interaction is predicted rather than demonstrated.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Gepirone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Gepirone belongs to Central Nervous System.
Why it happens
Theoretical CYP3A4 inhibition by entacapone reducing gepirone clearance; not clearly established clinically.
What to do
No routine dose change is needed. Monitor for dizziness, sedation and QT effects, and consider the labeled dose reduction only if a true moderate CYP3A4 inhibitor is also present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Gepirone?
MediHelp rates the interaction as minor. Carbidopa-entacapone-levodopa and Gepirone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gepirone is cleared mainly by CYP3A4, and inhibitors raise its exposure, increasing dizziness, sedation and QT prolongation. Entacapone is not an established CYP3A4 inhibitor, so the interaction is predicted rather than demonstrated.
How serious is the interaction between Carbidopa-entacapone-levodopa and Gepirone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for dizziness, sedation and QT effects, and consider the labeled dose reduction only if a true moderate CYP3A4 inhibitor is also present.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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