Drug interactions
Gepirone + Linezolid
Severity: Contraindicated
Gepirone and Linezolid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is contraindicated with MAO inhibitors, including linezolid, because of the risk of serotonin syndrome. Symptoms include agitation, hyperthermia, clonus and autonomic instability.
What this interaction means in plain words
Gepirone and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Gepirone belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
Why it happens
Additive serotonergic effects from serotonin receptor agonism and MAO inhibition.
What to do
Do not start gepirone within 14 days of stopping linezolid, and do not give linezolid to patients on gepirone unless urgent, then stop gepirone and monitor for serotonin toxicity.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Phenelzine Contraindicated
- Gepirone + Pimozide Contraindicated
Frequently asked questions
Can I take Gepirone with Linezolid?
MediHelp rates the interaction as contraindicated. Gepirone and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gepirone is contraindicated with MAO inhibitors, including linezolid, because of the risk of serotonin syndrome. Symptoms include agitation, hyperthermia, clonus and autonomic instability.
How serious is the interaction between Gepirone and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not start gepirone within 14 days of stopping linezolid, and do not give linezolid to patients on gepirone unless urgent, then stop gepirone and monitor for serotonin toxicity.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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