Drug interactions
Gepirone + Isocarboxazid
Severity: Contraindicated
Gepirone and Isocarboxazid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is contraindicated with MAOIs because of the risk of serotonin syndrome. Severe reactions can include hyperthermia, rigidity, autonomic instability and altered mental status.
What this interaction means in plain words
Gepirone and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Gepirone belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from MAO inhibition and gepirone's 5-HT1A agonism.
What to do
Do not coadminister. Allow at least 14 days after stopping an MAOI before starting gepirone, and at least 14 days after stopping gepirone before starting an MAOI.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
- Gepirone + Pimozide Contraindicated
Frequently asked questions
Can I take Gepirone with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Gepirone and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gepirone is contraindicated with MAOIs because of the risk of serotonin syndrome. Severe reactions can include hyperthermia, rigidity, autonomic instability and altered mental status.
How serious is the interaction between Gepirone and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow at least 14 days after stopping an MAOI before starting gepirone, and at least 14 days after stopping gepirone before starting an MAOI.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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