Drug interactions
Clarithromycin + Gepirone
Severity: Contraindicated
Clarithromycin and Gepirone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin increases gepirone exposure, which raises the risk of QT prolongation and adverse effects such as dizziness and sedation. Labeling contraindicates strong CYP3A4 inhibitors with gepirone.
What this interaction means in plain words
Clarithromycin and Gepirone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Gepirone belongs to Central Nervous System.
Why it happens
Clarithromycin inhibits CYP3A4, the main metabolic pathway of gepirone, and also prolongs the QT interval.
What to do
Do not coadminister; select a non-CYP3A4-inhibiting antibiotic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Gepirone
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
- Gepirone + Pimozide Contraindicated
Frequently asked questions
Can I take Clarithromycin with Gepirone?
MediHelp rates the interaction as contraindicated. Clarithromycin and Gepirone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin increases gepirone exposure, which raises the risk of QT prolongation and adverse effects such as dizziness and sedation. Labeling contraindicates strong CYP3A4 inhibitors with gepirone.
How serious is the interaction between Clarithromycin and Gepirone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; select a non-CYP3A4-inhibiting antibiotic.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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