Drug interactions
Gepirone + Phenelzine
Severity: Contraindicated
Gepirone and Phenelzine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is serotonergic and contraindicated with MAO inhibitors because of the risk of serotonin syndrome. Symptoms include agitation, hyperthermia, tremor, rigidity and autonomic instability.
What this interaction means in plain words
Gepirone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Gepirone belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity, with MAO inhibition preventing serotonin breakdown.
What to do
Do not combine. Wait at least 14 days after stopping phenelzine before starting gepirone, and at least 14 days after stopping gepirone before starting phenelzine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Pimozide Contraindicated
Frequently asked questions
Can I take Gepirone with Phenelzine?
MediHelp rates the interaction as contraindicated. Gepirone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gepirone is serotonergic and contraindicated with MAO inhibitors because of the risk of serotonin syndrome. Symptoms include agitation, hyperthermia, tremor, rigidity and autonomic instability.
How serious is the interaction between Gepirone and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Wait at least 14 days after stopping phenelzine before starting gepirone, and at least 14 days after stopping gepirone before starting phenelzine.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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