Drug interactions
Carbidopa-entacapone-levodopa + Hydrochlorothiazide
Severity: Moderate
Carbidopa-entacapone-levodopa and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, and hydrochlorothiazide lowers blood pressure through diuresis, so effects may add. Patients may have dizziness or falls, especially if volume depleted.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive hypotensive effects of levodopa and thiazide-induced volume depletion.
What to do
Monitor orthostatic blood pressure when starting or changing either drug. Reduce the thiazide dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, and hydrochlorothiazide lowers blood pressure through diuresis, so effects may add. Patients may have dizziness or falls, especially if volume depleted.
How serious is the interaction between Carbidopa-entacapone-levodopa and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when starting or changing either drug. Reduce the thiazide dose if symptomatic hypotension occurs.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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