Drug interactions
Carbidopa-entacapone-levodopa + Hyoscyamine
Severity: Moderate
Carbidopa-entacapone-levodopa and Hyoscyamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine is a centrally active anticholinergic that may add to antiparkinsonian effect but can slow gastric emptying and reduce levodopa absorption. It may also worsen dyskinesia, confusion, constipation and urinary retention, especially in older patients.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Hyoscyamine belongs to Genitourinary.
Why it happens
Anticholinergic delay of gastric emptying reduces levodopa absorption, with additive central anticholinergic effects.
What to do
Monitor motor response, cognition and anticholinergic adverse effects, and adjust levodopa timing or dose if control worsens. Prefer the lowest effective hyoscyamine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Hyoscyamine?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine is a centrally active anticholinergic that may add to antiparkinsonian effect but can slow gastric emptying and reduce levodopa absorption. It may also worsen dyskinesia, confusion, constipation and urinary retention, especially in older patients.
How serious is the interaction between Carbidopa-entacapone-levodopa and Hyoscyamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor response, cognition and anticholinergic adverse effects, and adjust levodopa timing or dose if control worsens. Prefer the lowest effective hyoscyamine dose.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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