Drug interactions
Aripiprazole + Hyoscyamine
Severity: Moderate
Aripiprazole and Hyoscyamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine is a potent antimuscarinic, and aripiprazole has weak anticholinergic activity. Combined use may add to dry mouth, constipation, urinary retention, tachycardia and confusion, particularly in older patients.
What this interaction means in plain words
Aripiprazole and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Hyoscyamine belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic effects including constipation, urinary retention and confusion. Use the lowest effective hyoscyamine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
- Carbidopa-entacapone-levodopa + Hyoscyamine Moderate
Frequently asked questions
Can I take Aripiprazole with Hyoscyamine?
MediHelp rates the interaction as moderate. Aripiprazole and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine is a potent antimuscarinic, and aripiprazole has weak anticholinergic activity. Combined use may add to dry mouth, constipation, urinary retention, tachycardia and confusion, particularly in older patients.
How serious is the interaction between Aripiprazole and Hyoscyamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects including constipation, urinary retention and confusion. Use the lowest effective hyoscyamine dose.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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