Drug interactions
Bethanechol + Hyoscyamine
Severity: Moderate
Bethanechol and Hyoscyamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine is an antimuscarinic that directly opposes bethanechol. Benefits on bladder emptying and gut motility may be lost.
What this interaction means in plain words
Bethanechol and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bethanechol belongs to Gastrointestinal Tract; Hyoscyamine belongs to Genitourinary.
Why it happens
Competitive muscarinic antagonism opposes bethanechol agonism.
What to do
Avoid concurrent use when bethanechol is given to stimulate motility. If both are required, monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bethanechol
- Bethanechol + Darifenacin Major
- Bethanechol + Fesoterodine Major
- Bethanechol + Oxybutynin Major
- Bethanechol + Physostigmine Major
- Amifampridine + Bethanechol Moderate
- Amitriptyline + Bethanechol Moderate
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Carbidopa-entacapone-levodopa + Hyoscyamine Moderate
Frequently asked questions
Can I take Bethanechol with Hyoscyamine?
MediHelp rates the interaction as moderate. Bethanechol and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine is an antimuscarinic that directly opposes bethanechol. Benefits on bladder emptying and gut motility may be lost.
How serious is the interaction between Bethanechol and Hyoscyamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when bethanechol is given to stimulate motility. If both are required, monitor clinical response.
What other medicines interact with Bethanechol?
MediHelp also lists interactions of Bethanechol with, for example, Darifenacin, Fesoterodine, Oxybutynin. The full list is on the Bethanechol page.
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