Drug interactions
Amitriptyline + Hyoscyamine
Severity: Moderate
Amitriptyline and Hyoscyamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, and combined use increases the risk of dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Older patients are at particular risk of delirium.
What this interaction means in plain words
Amitriptyline and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Hyoscyamine belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects.
What to do
Use the lowest effective doses and monitor for anticholinergic toxicity. Avoid in elderly patients, glaucoma, or urinary obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
- Carbidopa-entacapone-levodopa + Hyoscyamine Moderate
Frequently asked questions
Can I take Amitriptyline with Hyoscyamine?
MediHelp rates the interaction as moderate. Amitriptyline and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, and combined use increases the risk of dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Older patients are at particular risk of delirium.
How serious is the interaction between Amitriptyline and Hyoscyamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for anticholinergic toxicity. Avoid in elderly patients, glaucoma, or urinary obstruction.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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