Drug interactions
Atropine + Hyoscyamine
Severity: Moderate
Atropine and Hyoscyamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine is the active levo isomer of atropine, so the combination duplicates therapy and raises the risk of anticholinergic toxicity. Effects include dry mouth, tachycardia, urinary retention, constipation, confusion and hyperthermia.
What this interaction means in plain words
Atropine and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Hyoscyamine belongs to Genitourinary.
Why it happens
Additive muscarinic receptor antagonism from duplicate antimuscarinic agents.
What to do
Avoid concurrent use of both drugs. If necessary, reduce doses and monitor for anticholinergic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
- Carbidopa-entacapone-levodopa + Hyoscyamine Moderate
Frequently asked questions
Can I take Atropine with Hyoscyamine?
MediHelp rates the interaction as moderate. Atropine and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine is the active levo isomer of atropine, so the combination duplicates therapy and raises the risk of anticholinergic toxicity. Effects include dry mouth, tachycardia, urinary retention, constipation, confusion and hyperthermia.
How serious is the interaction between Atropine and Hyoscyamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of both drugs. If necessary, reduce doses and monitor for anticholinergic toxicity.
What other medicines interact with Atropine?
MediHelp also lists interactions of Atropine with, for example, Eluxadoline, Henbane, Pramlintide. The full list is on the Atropine page.
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