Drug interactions
Carbidopa-entacapone-levodopa + Metolazone
Severity: Moderate
Carbidopa-entacapone-levodopa and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, and metolazone's diuretic and antihypertensive effects may add to this. Patients, especially older adults, may experience dizziness or falls when treatment is started or doses are raised.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Metolazone belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering through pharmacodynamic effects of levodopa and volume depletion from the diuretic.
What to do
Check orthostatic blood pressure when starting or adjusting either drug. Lower the diuretic dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Metolazone
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Metolazone?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, and metolazone's diuretic and antihypertensive effects may add to this. Patients, especially older adults, may experience dizziness or falls when treatment is started or doses are raised.
How serious is the interaction between Carbidopa-entacapone-levodopa and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check orthostatic blood pressure when starting or adjusting either drug. Lower the diuretic dose if symptomatic hypotension develops.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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