Drug interactions
Carbidopa-entacapone-levodopa + Metyrosine
Severity: Moderate
Carbidopa-entacapone-levodopa and Metyrosine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metyrosine inhibits tyrosine hydroxylase and depletes catecholamines, whereas levodopa supplies dopamine precursor downstream of that enzyme. Metyrosine can also cause extrapyramidal symptoms and sedation, which may worsen parkinsonism and oppose levodopa benefit, and hypotension may add.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Metyrosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Metyrosine belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism of dopaminergic therapy by metyrosine catecholamine synthesis inhibition, with additive hypotension.
What to do
Monitor motor control and blood pressure closely. Consider an alternative to metyrosine in patients with Parkinson disease if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Metyrosine
- Carbidopa-levodopa + Metyrosine Major
- Fluphenazine + Metyrosine Major
- Metoclopramide + Metyrosine Major
- Chlorpromazine + Metyrosine Moderate
- Clonidine + Metyrosine Moderate
- Haloperidol + Metyrosine Moderate
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Metyrosine?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Metyrosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metyrosine inhibits tyrosine hydroxylase and depletes catecholamines, whereas levodopa supplies dopamine precursor downstream of that enzyme. Metyrosine can also cause extrapyramidal symptoms and sedation, which may worsen parkinsonism and oppose levodopa benefit, and hypotension may add.
How serious is the interaction between Carbidopa-entacapone-levodopa and Metyrosine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor control and blood pressure closely. Consider an alternative to metyrosine in patients with Parkinson disease if feasible.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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