Drug interactions
Metoclopramide + Metyrosine
Severity: Major
Metoclopramide and Metyrosine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metyrosine depletes catecholamines and can itself cause extrapyramidal symptoms, and metoclopramide blocks dopamine D2 receptors. Together the risk and severity of parkinsonism, dystonia and other movement disorders are increased.
What this interaction means in plain words
Metoclopramide and Metyrosine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Metoclopramide belongs to Gastrointestinal Tract; Metyrosine belongs to Miscellaneous.
Why it happens
Additive dopaminergic antagonism (metoclopramide) and dopamine synthesis inhibition (metyrosine).
What to do
Avoid the combination and choose a non-dopamine-blocking antiemetic or prokinetic. If unavoidable, monitor closely for extrapyramidal symptoms and stop metoclopramide at the first sign.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metoclopramide
Other interactions of Metyrosine
- Carbidopa-levodopa + Metyrosine Major
- Fluphenazine + Metyrosine Major
- Carbidopa-entacapone-levodopa + Metyrosine Moderate
- Chlorpromazine + Metyrosine Moderate
- Clonidine + Metyrosine Moderate
- Haloperidol + Metyrosine Moderate
Frequently asked questions
Can I take Metoclopramide with Metyrosine?
MediHelp rates the interaction as major. Metoclopramide and Metyrosine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metyrosine depletes catecholamines and can itself cause extrapyramidal symptoms, and metoclopramide blocks dopamine D2 receptors. Together the risk and severity of parkinsonism, dystonia and other movement disorders are increased.
How serious is the interaction between Metoclopramide and Metyrosine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-dopamine-blocking antiemetic or prokinetic. If unavoidable, monitor closely for extrapyramidal symptoms and stop metoclopramide at the first sign.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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