Drug interactions
Clonidine + Metyrosine
Severity: Moderate
Clonidine and Metyrosine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metyrosine inhibits catecholamine synthesis and causes sedation, and clonidine also reduces sympathetic activity and causes drowsiness. The combination may increase sedation and hypotension.
What this interaction means in plain words
Clonidine and Metyrosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Metyrosine belongs to Miscellaneous.
Why it happens
Additive CNS depression and sympathetic suppression through tyrosine hydroxylase inhibition and central alpha-2 agonism.
What to do
Monitor for excessive sedation and orthostatic hypotension, and advise against driving until tolerance is known. Adjust doses based on blood pressure and symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Metyrosine
- Carbidopa-levodopa + Metyrosine Major
- Fluphenazine + Metyrosine Major
- Metoclopramide + Metyrosine Major
- Carbidopa-entacapone-levodopa + Metyrosine Moderate
- Chlorpromazine + Metyrosine Moderate
- Haloperidol + Metyrosine Moderate
Frequently asked questions
Can I take Clonidine with Metyrosine?
MediHelp rates the interaction as moderate. Clonidine and Metyrosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metyrosine inhibits catecholamine synthesis and causes sedation, and clonidine also reduces sympathetic activity and causes drowsiness. The combination may increase sedation and hypotension.
How serious is the interaction between Clonidine and Metyrosine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and orthostatic hypotension, and advise against driving until tolerance is known. Adjust doses based on blood pressure and symptoms.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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